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This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from $200 million in 1950 to $1.2 billion in 2010 - has...

Featuring over 100 of the most significant and influential houses of the twentieth century, this book includes classic works by such seminal architects as Le Corbusier, Frank Lloyd Wright, Mies van der Rohe and Alvar Aalto, as well as those by more recent masters, such as Tadao Ando, Rem Koolhaas and Glen Murcutt. For each of the houses included...

In her new role as protector of the Siyee, Auraya investigates sightings of a landwalker stranger in their land. She meets a mysterious woman claiming to be a friend of Mirar's: a woman who makes an offer Auraya is unable to refuse, but which she must conceal or risk the wrath of the gods. In the south, Mirar enjoys acceptance and respect as he...

ROCK ROLL WOMAN GIVES ME THOSE ROCK ROLL BLUES Timid Yaya is the victim of every bully in school, but she has a secret kept even from herself: She has another personality named Nana, who is all too willing to kick butt. While nice-guy guitarist Moriyama begins a tentative romance with Yaya, the constant appearances of brash Nana reveal the truth...

"A model city, the hope of democracy" - John Nolan on his suggested plans for Madison, Wisconsin This book connects John Nolen's political and social visions with his design proposals by analyzing his extensive writings, personal correspondence and some of his most significant works. While John Nolen is best known as a city planner, he trained as...

Kimihiro Watanuki is haunted by spirits-and the only way to escape his curse is to become the indentured servant of the mysterious witch, Yűko Ichihara. But when his beloved, beautiful Himawari-chan, asks him for a favor, he and his eternal rival, the exorcist Dômeki, must go on a spirit-busting adventure without Yűko there to save them! Meanwhile...