Computational Approaches to Protein Dynamics -

Computational Approaches to Protein Dynamics
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Autor: ...

Wydawnictwo: CRC Press Inc.
ISBN: 9781466561571
EAN:
Format: ...
Oprawa: twarda
Stron: 479
Data wydania: 2014-12-01
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This groundbreaking work addresses a crucial paradigm shift in structural molecular biology, illustrating how protein dynamics plays a central role in various functions, including enzymatic catalysis, protein-protein interactions, and the organization of complex assemblies. The book presents modern computational techniques for the characterization of proteins and their dynamic properties. The computational methods specifically address the dynamical aspects of protein functionalities, with special emphasis on the analysis of complex assemblies and intrinsically disordered proteins. "The modeling of biological systems and processes has advanced remarkably in recent years, gradually becoming a legitimate field of research. It has also started to be clear that ... structural and kinetic findings emerging from experimental work should be augmented by computer simulations. Some of the progress in the field has been described in the scholarly articles compiled in this book. ... the reader should look at the present publication as a report that reflects the current developments in the field, and then make sure when picking a particular approach that this approach actually reproduces 'reality'." -From the Foreword by Nobel Laureate Ariel Warshel, Distinguished Professor of Chemistry and Biochemistry, University of Southern California "The book is conveniently structured to simplify the preparation of a new graduate course on biomolecular simulations." -Jan Florian, Department of Chemistry and Biochemistry, Loyola University Chicago "... a comprehensive assessment of the methods for modeling protein dynamics and conformational heterogeneity across multiple spatial and time scales. Each contribution attempts to point the way toward connecting dynamics and heterogeneity to molecular function, thus making for a compelling read." -Rohit V. Pappu, Department of Biomedical Engineering, Washington University, St. Louis

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