EBOOK Kinase Inhibitor Drugs - Rongshi Li

EBOOK Kinase Inhibitor Drugs
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Autor: Rongshi Li

 Wydawnictwo: Wiley
ISBN: 9780470524954
EAN: A303CD85EB
Format: 0,0 x 0,0 x 0,0
Oprawa: ...
Stron: 480
Data wydania: 2009
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A comprehensive resource on case studies of marketed kinase drugs and promising drug trialsSince the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development.In one comprehensive volume, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, present timely and important case studies of marketed kinase drugs and several of the most advanced kinase inhibitors in clinical trials. Kinase Inhibitor Drugs includes:Case studies from leading investigators and experts in the field that provide firsthand accounts of kinase inhibitor discoveryCurrent thinking on kinase structure, biochemistry, and signal transduction pathwaysInformation on state-of-the-art technologies and tools such as structure-based and fragment-based drug discoveryA lineup of clinical-phase growth factor receptor inhibitorsInhibitors of cell cycle kinasesThe discovery of allosteric inhibitors of MEK kinaseInformation on pharmacogenomics and its application to kinase inhibitor clinical development

Książka "EBOOK Kinase Inhibitor Drugs"
Rongshi Li