EBOOK Bioisosteres in Medicinal Chemistry -

EBOOK Bioisosteres in Medicinal Chemistry
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Wydawnictwo: Wiley
ISBN: 9783527654338
EAN: 37E54F95EB
Format: 0,0 x 0,0 x 0,0
Oprawa: ...
Stron: 256
Data wydania: 2012
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Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third partcovers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays ofprotein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

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